Tumor-suppressing miRNAs
نویسندگان
چکیده
منابع مشابه
Tumor Suppressing Pathways
The search for the tumor suppressor gene on 18q Identification of the cell regulatory genes that drive carexemplifies this challenge. The initial candidate gene cinogenesis is one of the major goals in cancer research, identified in the 18q region, DCC, seemed at first to resulting in new anticancer drug targets and new therameet the appropriate criteria for a tumor suppressor peutic and diagno...
متن کاملTumor-suppressing 15-Lipoxygenase-2
Lipoxygenases (LOX) comprise a family of non-heme-iron-containing proteins that cata-lyze the dioxygenation of polyunsaturated fatty acids to form bioactive lipids. Metabolism of arachidonic acid by LOXs leads to the formation of regioisomeric cis/trans-conjugated hydroxyeicosatetraenoic acids (HeTes), leukot-rienes, lipoxins, and hepoxilins. Dependent on the predominant position of the incorpo...
متن کاملThe Tumor Cytosol miRNAs, Fluid miRNAs, and Exosome miRNAs in Lung Cancer
The focus of this review is to provide an update on the progress of microRNAs (miRNAs) as potential biomarkers for lung cancer. miRNAs are single-stranded, small non-coding RNAs that regulate gene expression and show tissue-specific signatures. Accumulating evidence indicates that miRNA expression patterns represent the in vivo status in physiology and disease. Moreover, miRNAs are stable in se...
متن کاملmiRNAs confer phenotypic robustness to gene networks by suppressing biological noise
miRNAs are small non-coding RNAs able to modulate target gene expression. It has been postulated that miRNAs confer robustness to biological processes, but clear experimental evidence is still missing. Here, using a synthetic biological approach, we demonstrate that microRNAs provide phenotypic robustness to transcriptional regulatory networks by buffering fluctuations in protein levels. We con...
متن کاملDNA Methylation of Tumor Suppressive miRNAs in Non-Hodgkin’s Lymphomas
DNA methylation is an epigenetic alteration leading to heritable phenotypic changes of cells with functional consequences. It is important in early embryonic development, stem cell differentiation, and tissue-specific gene expression. In normal cells, promoter-associated CpG islands (CGI) are generally unmethylated except in X-chromosome inactivation or genomic imprinting. In cancer, tumor cell...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Science-Business eXchange
سال: 2009
ISSN: 1945-3477
DOI: 10.1038/scibx.2009.1031